EBP integrates the best available research evidence with clinical expertise and patient values to improve outcomes. The process involves asking a relevant clinical question (PICO), finding the best evidence to answer it, applying the evidence to practice, and evaluating the evidence based on clinical outcomes. For example, implementing a new evidence-based clinical practice guideline at an institution to reduce or prevent chemotherapy extravasation for patients receiving vesicant therapy, for adult acute care medical surgical patients receiving blood transfusions, what are the best monitoring practice to assess for the incidence of adverse transfusion reactions? Does the evidence say that manual vs. Automatic blood pressures as most accurate?